The article examines at the regional level such indicators as population size, in particular, growth rates and the share of the economically active population, employment and unemployment levels, changes in the ratio of urban and rural populations, as sources of formation of the labor market. An analysis of regional similarities and differences in the dynamics of these indicators has been carried out. Based on the analysis of the trend in the share of the region's population in the country's population, it is assumed that this social process is an important factor in the economic process associated with the formation of labor resources and optimization of the labor market. In recent years, changes in the ratio of urban and rural populations have been assessed as a factor causing regional differences in the relative rates of the economically active population. It was revealed that the sources of formation of the labor market create a trend of change in the same time periods. It is explained that the jump points of unemployment levels in the regions are connected with the strong fluctuations in the growth picture of the economically active population. This is also based on the fact that the growth rate of the unemployment rate is not collinear with the growth rate of the economically active population.

In recent years, the processes of economic modernization, urbanization, and the existence of interregional socio-economic disparities in the Republic of Uzbekistan have made the issue of internal migration even more urgent. The migration of the population from one region to another usually leads to significant changes in the territorial distribution of labor resources. In particular, the migration flow from rural areas to cities, from economically active regions to central cities, directly affects the composition of the labor market and employment indicators.