In the process of expanding foreign economic relations of Uzbekistan, the article examines the ways of coordinating the organizational basis of coordination relations and the mechanisms for their development within the framework of the cooperation development system associated with the Shanghai Cooperation Organization. The impact of existing problems on the process of establishing large-scale trade and economic relations between the member states of the Shanghai Cooperation Organization and the Republic of Uzbekistan is analyzed. Within the framework of the Shanghai Cooperation Organization, a scientific proposal and practical recommendations on the system for expanding Uzbekistan's foreign economic relations and the directions for its coordination have been developed.